Borage seed oil comes from the seed Borago officinalis (borage).
Borage seed oil has one of the highest amounts? -linolenic acid (GLA) from seed oil - higher than blackcurrant seed oil or evening primrose oil, considered the same. GLA typically consists of about 24% oil.
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Effects
GLA changed to dihomo -? - linolenic acid (DGLA), a precursor for various 1-series prostaglandins and 3-series leukotrienes. This inhibits leukotriene synthesis to provide therapy in rheumatic diseases. Borage seed oil may have anti-inflammatory and anti-thrombotic effects and has been studied because of its potential to treat inflammatory disorders, arthritis, atopic eczema, and respiratory inflammation.
Usage
In herbal medicine, borage seed oil has been used for skin disorders such as eczema, seborrheic dermatitis, and neurodermatitis; it has also been used for rheumatoid arthritis, stress, premenstrual syndrome, diabetes, attention deficit-hyperactivity disorder (ADHD), acute respiratory distress syndrome (ARDS), alcoholism, pain and swelling (inflammation), and to prevent heart disease and stroke. There is not enough scientific evidence to determine the effectiveness of borage for most of these uses.
Several clinical studies have shown it to be ineffective for treating atopic eczema. Khasiatnya to treat eczema is not better than placebo when taken orally.
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Adverse effects
Borage oil may contain pyrrolizidine alkaloid amabiline, which is hepatotoxic which causes the risk of liver damage. Patients should use certified borage oil-free from toxic unsaturated pyrrolizidine alkaloids (UPAs). Consumption of 1-2 g of borage seed oil every day can result in toxic UPA intake approaching 10 ug. The Federal Health Agency of Germany stipulates that consumption is limited to 1% of UPA daily.
Borage oil may be unsafe during pregnancy because preliminary studies suggest borage oil has a teratogenic effect and that prostaglandin E agonist action can cause premature labor.
Seizures have been reported as complications of borage oil consumption in doses of 1,500 to 3,000 mg daily, although a mixed review of the effects of borage oil on the seizure threshold suggests that the quality of borage oil varies. Certain extraction processes can offer refined products with 50% GLA content.
Borage seed oil can lengthen bleeding time, increase bruising and bleeding risks, and increase the risk of bleeding during and after surgery.
Interactions
Because borage oil can theoretically lower the seizure threshold due to its GLA content, it can trigger seizures in phenothiazine or tricyclic antidepressants.
The use of NSAIDs with borage oil can theoretically decrease the effect of borage oil, as NSAIDs interfere with prostaglandin E synthesis.
References
Source of the article : Wikipedia
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